Guanfacine (Intuniv) for Attention-Deficit/Hyperactivity Disorder
Guanfacine, sold under the brand name Tenex among others, is an oral medication used to treat attention deficit hyperactivity disorder (ADHD) and high blood pressure. It is not considered a first-line treatment for either indication. Common side effects include sleepiness, constipation, dry mouth, sexual problems, and headaches. Other side effects may include anxiety, low blood pressure. Mar 05, · Guanfacine works by relaxing blood vessels, which lowers blood pressure and improves blood flow. The Tenex brand of guanfacine is used to treat high blood pressure (hypertension). It is sometimes given with other blood pressure medications. The Intuniv brand of guanfacine is used to treat attention deficit hyperactivity disorder.
Guanfacine tablets Tenex are used alone or in combination with other medications to treat high blood pressure. Gaunfacine extended-release long-acting tablets Intuniv are used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age in children.
Guanfacine is in a class of medications what is in a capacitor centrally acting alpha 2A -adrenergic receptor agonists. Guanfacine treats high blood pressure by decreasing heart rate and relaxing the blood vessels so that blood can flow more easily through the body. Guanfacine extended-release tablets may treat ADHD by affecting the part of the brain that controls attention and impulsivity.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may guantacine heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet fpr is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.
Guanfacine comes as a tablet and as an extended-release tablet to take by mouth. The tablet hcildren usually taken once a day at bedtime. The extended-release tablet is usually taken once a day and should not ih taken with a high fat meal. Take guanfacine at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take guanfacine what is rational choice institutionalism as directed. Chiildren not take more or less of it or take it more often than prescribed by your doctor. Swallow the extended-release tablets whole with a small amount of water or another liquid; do not break, chew, or crush them.
Your doctor will probably start you on a low dose of guanfacine and may gradually increase your dose, iss more often than once a week if you are taking the extended-release tablets, and not more often than once every weeks if you are taking the tablets. Guanfacine may control your condition, but will not cure ih. It may take 2 weeks before you feel the full benefit of guanfacine extended-release tablets. Continue to take guanfacine even if you feel well.
Do not stop taking guanfacine without talking to your doctor. If you suddenly stop taking guanfacine, your blood pressure may increase and you may become nervous or anxious. Your doctor will probably decrease your dose gradually. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medication. Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are taking guanfacine extended-release tablets, and miss two or more doses in a row, call your doctor. Guanfacine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet.
Instead, the best way to dispose of your medication is through a medicine take-back program. In case of childfen, call the poison control us at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor.
Your blood pressure and heart rate should be checked regularly to determine your response to guanfacine. Do not let what is guanfacine used for in children else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital.
It is also important information to carry with you in case of emergencies. Guanfacine pronounced as gwahn' fa seen.
Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow?
What should I do if I forget a dose? What side effects can this medication cause? What should I know about storage and disposal of this medication? Brand names. Other uses for this medicine. What special precautions should I follow? Before taking guanfacine, tell your doctor and pharmacist if you are allergic to guanfacine, any what are the steps to becoming a police officer medications, whatt any of the ingredients in guanfacine tablets what your car says about you bmw extended-release tablets.
Ask your pharmacist for a list of the ingredients. Do not take both of these products at the same time. Be sure to mention any of the following: antidepressants; antihistamines; barbiturates such as phenobarbital Luminal ; carbamazepine Carbatrol, Epitol, Equetro, Tegretol ; clarithromycin Biaxin, in PrevPac ; indinavir Crixivan ; itraconazole Onmel, Sporanox ; ketoconazole Nizoral ; medications for anxiety, high blood pressure, mental illness, nausea, or seizures; nefazodone; nelfinavir Viracept ; phenytoin Dilantin, Phenytek ; pioglitazone Actos, in Actoplus Met, in Duetact, in Oseni ; rifabutin Mycobutin ; rifampin Rifadin, in Rifamate, in Rifater, Rimactane ; ritonavir Norvir, in Kaletra ; sedatives; sleeping pills; tranquilizers; and valproic acid Depakene.
Your childfen may need to change the doses of your medications or monitor you carefully for side effects. John's wort. If you become pregnant while taking guanfacine, call your doctor. Do not drive a car or operate machinery until you know how this medication affects you. Alcohol can make the side effects from guanfacine worse. This is more common when you first start taking guanfacine.
To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Be sure to drink plenty of liquids and stay cool while you are taking this medication. Older adults should not usually take guanfacine because it is not as safe or effective as other medications that can be used to treat the same condition. Guanfacine may cause side effects. If cchildren experience any of the following symptoms, call your doctor immediately: fainting blurred vision rash slow heart rate Guanfacine may cause other side effects.
Symptoms of overdose may include: drowsiness lack of energy slow heart rate fainting dizziness blurred vision smaller pupils black circles in the middle of the eyes. What other information should I know?
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Intuniv (guanfacine) is used to treat attention deficit hyperactivity disorder (ADHD)
Currently, guanfacine ER is FDA approved only for use in children who are 6 through 17 years old. It has not been studied and approved by the FDA for the treatment of ADHD in children younger than the age of 6 or in adults over the age of The immediate-release formulation of guanfacine is used to treat high blood pressure. Guanfacine (Tenex, Intuniv) How does this medicine work? Guanfacine (gwan-fa-seen) is used to treat high blood pressure. It may also be used to treat symptoms of attention deficit and hyperactivity disorder (ADHD). Symptoms of ADHD include short attention span, impulsivity (acting on sudden urges), and frequent hyperactivity (body restlessness). Dec 01, · Exposure to guanfacine was higher in children (ages 6 to 12) compared to adolescents (ages 13 to 17) and adults. After oral administration of multiple doses of guanfacine extended-release tablets 4 mg, the C max was 10 ng/mL compared to 7 ng/mL and the AUC was ng·h/mL compared to ng·h/mL in children (ages 6 to 12) and adolescents.
Enlarge Print. Guanfacine can cause hypotension, although it does not cause symptoms in most patients, and changes in blood pressure are usually small. Approximately 1 percent of children taking guanfacine will experience orthostatic hypotension.
Syncope also occurs in about 1 percent of children, but it is not clear whether this is related to the drop in blood pressure or is a separate adverse effect. Changes on electrocardiography, including bradycardia, are rare but have occurred in clinical trials. Abrupt withdrawal of guanfacine should be avoided to decrease the risk of notable changes in blood pressure. Guanfacine is U. Food and Drug Administration pregnancy category B. Sedation is common with guanfacine treatment and can be severe in a small number of children.
Somnolence and fatigue are also common, affecting 9 to 40 percent of children. In clinical trials, 12 percent of patients taking guanfacine discontinued therapy, compared with 4 percent of those taking placebo. The most common reasons for discontinuation were somnolence and sedation.
As with short-term therapy, the adverse effects from long-term therapy generally decrease over time. Guanfacine is effective in the short-term i. Dosages of 1 to 4 mg per day decrease scores on the ADHD Rating Scale-IV by an average of 17 to 21 points, compared with a decrease of 9 to 12 points with placebo. Both physician ratings and parent assessments expressed marked improvement in more children receiving guanfacine compared with those receiving placebo. About twice as many children receiving guanfacine had statistically significant improvement on the Clinical Global Impressions Improvement scale.
Similarly, 36 to 62 percent of patients taking guanfacine had statistically significant improvement on the Parent Global Assessment scale compared with 30 percent of those taking placebo.
The duration of action of guanfacine, at least at lower dosages, is no more than eight hours, and higher dosages may be needed to produce sustained effectiveness.
The starting dosage of guanfacine is 1 mg per day. The dosage can be titrated up in increments of 1 mg per week to a maximum dosage of 4 mg per day. Tablets should not be chewed or crushed. Guanfacine should be given on a daily basis for the entire week, not just on school days, to avoid issues with returning or worsening somnolence and potential, but rare, increases in blood pressure.
Patients who miss two or more consecutive doses may need to restart therapy at 1 mg per day and then titrate the dosage up based on patient tolerability. To discontinue guanfacine, the dosage should be tapered by 1 mg every three to seven days.
Guanfacine is an effective short-term treatment option for ADHD in children six to 12 years of age. Sedation is a marked problem in many children. Patients should take the medication daily to avoid adverse effects that occur with abrupt discontinuation or when the guanfacine is restarted.
Already a member or subscriber? Log in. Reprints are not available from the author. Intuniv guanfacine extended-release tablets [product information]. Wayne, Pa. Accessed March 3, J Atten Disord. Long-term, open-label extension study of guanfacine extended release in children and adolescents with ADHD.
CNS Spectr. J Child Adolesc Psychopharmacol. Each independent review is provided by authors who have no financial association with the drug manufacturer. This content is owned by the AAFP. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP.
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